In this issue of JAMA, Johnston and colleagues begin to address this knowledge gap by providing data to inform clinical care and highlighting persistent research questions through a prospective cohort study of volunteers with first-episode genital HSV-1 infections. Until now, knowledge of the natural history of genital HSV-1 infections has been limited to observational studies with small numbers of patients. Thus, the true prevalence of and optimal management strategies for HSV-1 genital infection are lacking. Although currently available serology can determine the overall prevalence of HSV-2 infections, commercially available serological tests for HSV-1 perform relatively poorly, 5 and no serologic test has been developed to distinguish individuals who have genital HSV-1 infection from those with oropharyngeal HSV-1 infection. 2 - 4ĭifferences in the shedding patterns, clinical manifestations, and management between genital herpes caused by HSV-1 and HSV-2 are poorly described. However, over the past 2 decades, HSV-1 has been recognized as an increasing cause of genital infections and accounts for an estimated greater than 50% of new infections among some subpopulations, such as college students and heterosexual women. Thus, the reservoir of individuals infected with HSV continues to increase.įor the most part, knowledge about genital HSV infections is predicated on studies of infections caused by HSV-2. 1 There is no cure for HSV infection consequently, infection can be transmitted from individual to individual, most often because of asymptomatic viral shedding. Genital herpes simplex virus (HSV) infections are among the most common sexually transmitted infections encountered by humans and, in 2018, were estimated to occur in approximately 27% of US adults. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.
Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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